pcp analogues

PCP (Phencyclidine) is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects[2]. It is also known as “angel dust” among other names. PCP may cause hallucinations, distorted perceptions of sounds, and violent behavior. As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected. It may also be mixed with cannabis or tobacco[2].

PCP analogs are compounds that show structural similarity to PCP and have similar effects. Fewer than 30 different analogs of PCP were reported as being used on the street during the 1970s and 1980s, mainly in the United States. Only a few of these compounds were widely used, including rolicyclidine (PCPy), eticyclidine (PCE), and tenocyclidine (TCP). Less common analogs include 3-HO-PCP, 3-MeO-PCMo, and 3-MeO-PCP[2][5].

There is very limited information on the PCP analogs. However, a study showed that the PCP analog N-[1-(2-benzo(b)thiophenyl) cyclohexyl]piperidine (BTCP, GK13) is a potent DA uptake inhibitor, but has low affinity for PCP receptors. PCP receptors, but not DA uptake mechanisms, may mediate the cocaine-like behavioral effects of PCP, ketamine, and MK-801, because their order of potency in producing these effects (MK-801 greater than PCP greater than ketamine) is consistent with their potency order at PCP receptors, but not at DA uptake sites[3].

PCP analogues, also known as phencyclidine analogues or analog drugs, are chemical compounds that are structurally related to phencyclidine (PCP) and often share some of its psychoactive properties. These analogues are typically designed to mimic the effects of PCP, which is a dissociative anesthetic drug. The use of PCP analogues can lead to hallucinogenic, anesthetic, and sometimes, stimulant effects. Some common PCP analogues include:

  1. Ketamine: Ketamine is one of the most well-known PCP analogues. It is used as an anesthetic in medical settings but is also known for its dissociative and hallucinogenic effects when used recreationally.
  2. Methoxetamine (MXE): Methoxetamine is a synthetic compound that is structurally similar to ketamine. It has gained popularity as a recreational drug and is used for its dissociative and hallucinogenic effects.
  3. 3-MeO-PCP: This is another PCP analogue that has been synthesized for its psychoactive effects. It is used recreationally and is known for its hallucinogenic properties.
  4. 4-MeO-PCP: This is a close relative of 3-MeO-PCP and has similar effects, including hallucinations and dissociation.
  5. 3-MeO-PCE: Like other PCP analogues, 3-MeO-PCE produces dissociative and hallucinogenic effects when consumed.

It’s important to note that PCP and its analogues can be associated with significant risks and side effects, including hallucinations, disorientation, agitation, and even psychosis. These substances can be dangerous when used recreationally, and they may have unpredictable effects on individuals. Many PCP analogues are controlled substances and illegal in many jurisdictions.

The use of these substances should be avoided, and individuals should be aware of the legal and health risks associated with them. It is always safer to avoid the use of unregulated and potentially dangerous psychoactive substances.

Here are some of the more well-known PCP analogs on the market today[5]:

  • O-PCE
  • 3-HO-PCP
  • 3-MEO-PCP
  • 3-MEO-PCE
  • 3-Flouro-PCP
  • 4-MeO-PCP

It is important to note that PCP is a Schedule II substance in the United States and its ACSCN is 7471. Its manufacturing quota for 2014 was 19 grams. It is a Schedule I drug by the Controlled Drugs and Substances Act in Canada[2].

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC393481/
[2] https://en.wikipedia.org/wiki/Phencyclidine
[3] https://pubmed.ncbi.nlm.nih.gov/2674416/
[4] https://www.unodc.org/LSS/SubstanceGroup/Details/6bf165ed-82e7-47e0-9eaa-daacc42d99cd
[5] https://tripsitter.com/pcp/
[6] https://www.sciencedirect.com/science/article/pii/S037907381930547X

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